More than 17,155 people from 16 countries and 43 states attended, with millions more watching in more than 90 countries. Tickets sold out in under two minutes, grossing US$2.5 million for the event, making it the highest grossing one-day event at the Allstate Arena.

WrestleMania 22 was the third WrestleMania to take place in the Chicago metropolitan area (following WrestleMania 2, and WrestleMania 13). Featured matches on the undercard included a No Holds Barred match between Shawn Michaels and Vince McMahon, a Casket match between The Undertaker and Mark Henry, a WWE Women's Championship match between Mickie James and Trish Stratus and an interpromotional Money in the Bank ladder match featuring six participants. Mysterio won the match and the World Heavyweight Championship after pinning Orton following a 619 and a West Coast Pop. The predominant match on the SmackDown! brand was a Triple Threat match for the World Heavyweight Championship between champion Kurt Angle, Rey Mysterio, and Randy Orton. The main match on the Raw brand was John Cena versus Triple H for the WWE Championship, which Cena won after forcing Triple H to submit to the STF.

There were two main events which were the main matches for each brand. The event was a joint-promotion pay-per-view (PPV) featuring performers from the Raw and SmackDown! brands. It was presented by Snickers and took place on Apat the Allstate Arena in the Chicago suburb of Rosemont, Illinois. Backlash WrestleMania 22 was the twenty-second annual WrestleMania professional wrestling pay-per-view event produced by World Wrestling Entertainment (WWE).

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